7-OH binds strongly to mu-opioid receptors — the same receptors targeted by many traditional pain relievers — but it does so in a unique, G-protein-biased way.
This means it activates relief pathways while avoiding heavy triggering of beta-arrestin, the pathway associated with typical opioid side effects like constipation, respiratory depression, and high addiction potential.

• Potent, fast-acting support for relief without heavy sedation

• Lower risk of tolerance buildup compared to traditional opioids

• Potential antidepressant-like effects for emotional balance

• Clean-label, plant-derived — no synthetic additives

• Reduced side effect profile (less risk of addiction, respiratory issues)

• Potent, fast-acting support for relief without heavy sedation

• Lower risk of tolerance buildup compared to traditional opioids

• Potential antidepressant-like effects for emotional balance

• Clean-label, plant-derived — no synthetic additives

• Reduced side effect profile (less risk of addiction, respiratory issues)

Mitragynine is another compound found in kratom, but 7-Hydroxy is much more potent at activating mu-opioid receptors.
Research shows that 7-OH is the primary driver behind kratom’s effectiveness — providing stronger relief with less risk of dependency compared to mitragynine alone.

Preclinical studies suggest that 7-Hydroxy provides relief without the rapid tolerance buildup seen in traditional opioids like morphine.
This makes it a promising option for those seeking reliable, sustainable support.

While research is ongoing, early studies suggest that 7-Hydroxy offers a safer profile compared to conventional pain medications.
It provides strong effects without heavily activating beta-arrestin, which is often linked to dangerous side effects.

As with any supplement, we recommend consulting your doctor before use.

Current research indicates that 7-Hydroxy has lower abuse potential compared to traditional opioids.
Its unique action on receptors reduces the pathways typically associated with addiction — but responsible use is always essential.

7-Hydroxy is a natural metabolite of mitragynine, formed in the liver after consumption, and is also present in kratom leaves.
Pure Indo products feature standardized, plant-based 7-Hydroxy formulations to ensure clean, consistent support.

At Pure Indo, we focus on clean sourcing and lab-tested consistency.
Our products are made from ethically harvested plants and carefully standardized to deliver reliable, effective 7-Hydroxy support — no fillers, no shortcuts.